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CCR5
CCR5 (C-C motif chemokine receptor 5, also known as CD195) is a G protein-coupled receptor expressed on dendritic cells, T cells and macrophages. Its endogenous ligands such as CCL4 activate Gi signaling, leading to reduced intracellular cAMP. CCR5 serves as a core co-receptor for HIV entry into immune cells and is a promising target for anti-infection and anti-inflammatory drug discovery. Our CCR5 stable CHO-K1 cell lines have been validated in cAMP assays to support your drug discovery programs.