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CHRM1 (Cholinergic Receptor Muscarinic 1) is a G protein-coupled receptor abundant in the cerebral cortex and hippocampus. Acetylcholine binding activates Gq/11 signaling, triggering intracellular calcium mobilization and IP1 accumulation. It regulates cognition and memory, serving as a key target for neurological disorder therapeutics. Our CHRM1 stable CHO-K1 cell lines have been validated in IP1 assays to support your drug discovery programs.