GPCR Reporter Cells

Immunotherapy cells

Other Stable Cells

Assay Kits & Reagents

GPCR Reporter Cells

Based on extensive experience in constructing stable cell lines, we have engineered cells to co-express GPCR target proteins and their downstream signaling genes

Class A（Rhodopsin）

5-HTR ADORA1 ADORA2 ADORA3 ADRA1 ADRB2 AGTR1 APJ AVPR2 C3aR C5aR1 CB1 CB2 CCR1 CCR10 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9 CHRM1 CHRM2 CHRM3 CHRM4 CHRM5 CRTH2 CX3CR1 CXCR1 CXCR2 CXCR3 CXCR4 CXCR5 CXCR6 CXCR7 DRD1 DRD2 DRD3 DRD4 DRD5 EDG1 EDNRA EDNRB FPR1 FPR2 FSHR GNRHR GPBAR1 GPR120 GPR174 GPR183 GPR34 GPR40 GPR43 GPR52 GPR54 HCAR1 LHCGR MAS1 MC4R MRGPR MRGPRX1 MRGPRX2 NK1R NK2R NK3R NMBR NPY1R NPY2R NPY4R NPY5R NTSR1 OPRD1（DOR） OPRK1（KOR） OPRL1（NOP） OPRM1（MOR） OX1R OX2R OXTR PTGER2 PTGER4 RXFP1 SSTR1 SSTR2 SSTR3 SSTR4 SSTR5 TAAR1 TSHR

Class B1（Secretin）

CGRP1 CRF1R CRFR2 CTR GCGR GHRHR GIPR GLP1R GLP2R PAC1R PTH1R PTH2R SCTR VPAC1 VPAC2 XCR1

Class C（Glutamate）

CaSR GABA GPRC5D GRM4

Combination

GLP1R&GCGR GLP1R&GCGR&GIPR GLP1R&GIPR

Orphan and other 7TM

GPR55 GPR75 MRGPRB2

Parental Cell

Immunotherapy cells

Based on extensive experience in constructing stable cell lines, we have engineered cells to co-express GPCR target proteins and their downstream signaling genes

Combination

PD1&CTLA4 PD1&TIGIT PDL1&CD155

Fc Effector

ADCC/ADCP FcγR FcεRI

T Cell Activation

Other TCE

Co-Stimulatory

4-1BB BAFF BCMA CD27-CD70 CD28-CD80/86 CD40 DR3-TL1A GITR-GITRL HVEM-LIGHT ICOS-ICOSL ICOSL LTBR NCR1 NCR3 NKG2D-MIC OX40 PGLYRP1 TACI TMIGD2-HHLA2 TREM1 TREM2

Co-Inhibitory

BTLA-HVEM CD160 CD161-CLEC2D CD200-CD200R CD96 CTLA4 HLA-G KIR2DL5A KIR2DL5B KIR3DL2 KIR3DL3-HHLA2 LAG3 LAIR1 LILRB1 LILRB2 LILRB4 NKG2A-HLA-E PD1-PDL1/2 PILR PVRIG-CD112 SIRPɑ-CD47 TIGIT-CD155 TIM-3 VISTA

Immune Checkpoint

BDCA2 CD24 VSIG4

STING

Other

Cytokine&Growth Factor

Activin BNP/NPR1 c-KIT CSF1R EGFR EPO ERBBs FGF21/KLB FGFR FGFR1 FGFR2 GDF GHR GM-CSF IFN IGF1R IL1 IL10 IL11 IL12 IL17/IL25 IL18 IL19/IL20/IL22/IL24 IL2/IL15 IL21 IL23 IL27 IL3 IL31 IL33 IL36 IL4/IL13 IL5 IL6 IL7 IL9 Insulin Integrin NGF Notch1 NPR2 OSMR PDGF PRL RANK-RANKL TGF-β1 TIE2 TNFα TPO-TPOR TRKB TSLP VEGF WNT

TAA

5T4 ACP3 ADAM9 ASCT2 B7H3 B7H4 CD123 CD147 CD166 CD19 CD2 CD20 CD22 CD228 CD30 CD33 CD38 CD4 CD44 CD46 CD54 CD56 CD7 CD73 CD8 CD94 CD99 CDCP1 CDHs CEACAMs CLDN18.2 CLDN6 CLDNs DDR1 DLK1 DLL3 ENPP3 EрCAM FAP FCRL5 FRα GPC1 GPC3 GPC33 GUCY2C HLA0201 KLK2 LRRC15 LY6E LY6G6D MERTK MET MSLN MUCs Nectin4 PRAME /HLA0201 PSMA PTK7 ROR1 ROR2 SEZ6 SLC34A2 SLC39A6 SLITRK6 SORT1 STEAP1 STEAP1B2 STEAP2 TF TFRC TM4SF1 TREM2 TROP2

TLR

TLR2 TLR3 TLR4 TLR5 TLR7 TLR8 TLR9

Other Stable Cells

Based on extensive experience in constructing stable cell lines, we have engineered cells to co-express GPCR target proteins and their downstream signaling genes

Signaling pathway cells

Tracer Cell

Nuclear Receptor

Ion Channel

MUSK

Transporter

Other

Assay Kits & Reagents

Based on extensive experience in constructing stable cell lines, we have engineered cells to co-express GPCR target proteins and their downstream signaling genes

Assay Kits

Reagents

Services

Stable Cell Line Development

GPCR Cell-Based Assays

Immuno-Oncology Cell Models

Kinase Screening Platforms

PROTAC Degradation Models

ADC Target Cell Models

Molecular Biology Services

Drug Safety & Toxicology

Gene Editing Services

Stable Cell Line Development

We offer comprehensive solutions for stable cell line generation, including lentiviral integration, Flp-FRT site-specific integration, plasmid random integration, electroporation-based plasmid integration, and transposon-mediated integration.

Flp-FRT Targeted Integration Lentiviral Integration Plasmid Electroporation Random Plasmid Integration Transposon-Based Integration

GPCR Cell-Based Assays

Our GPCR assay services focus on the development, optimization, and validation of robust cellular models. These models are designed to accurately and reproducibly reflect compound-GPCR interactions, providing a reliable foundation for.... high-throughput screening and lead optimization.

GPCR Assay Development GPCR Assay Optimization GPCR Assay Validation

Immuno-Oncology Cell Models

We specialize in the development, optimization, and validation of cellular models for immuno-oncology targets. As your strategic partner, we are committed to enhancing your R&D success ...

Immuno-Oncology Assay Development Immuno-Oncology Assay Optimization Immuno-Oncology Assay Validation

Kinase Screening Platforms

We provide end-to-end cell-based model development services for kinase-targeted drug screening. Our approach centers on the development, optimization, and validation of kinase assays at the ....

Kinase Assay Development Kinase Assay Optimization Kinase Assay Validation

PROTAC Degradation Models

A key challenge in PROTAC development lies in accurately predicting and optimizing degradation efficacy, rather than mere binding affinity. Our PROTAC target model services are ...

PROTAC Degradation Assay Optimization PROTAC Degradation Assay Development PROTAC Degradation Assay Validation

ADC Target Cell Models

As ADC drug development advances beyond simple payload delivery, there is a growing need to evaluate differentiated mechanisms of action. Our ADC target model services provide a sophisticated platform for in-depth mechanistic insight.

ADC Assay Development ADC Assay Optimization ADC Assay Validation

Molecular Biology Services

We deliver comprehensive and precise molecular biology solutions to support life science research and biopharmaceutical development. Key services include CRISPR-Cas9 sgRNA library synthesis, STR profiling, and quantitative real-time PCR.

Cell Line Authentication by NGS Digital PCR (dPCR) Quantitative PCR (qPCR) STR Authentication

Drug Safety & Toxicology

With extensive expertise in in vitro pharmacology, we continuously innovate to meet evolving industry needs. Our integrated evaluation system—spanning cell biology, biochemistry, and molecular biology—provides a complete suite of in vitro ...

Gene Editing Services

Leveraging cutting-edge platforms such as CRISPR-Cas9, we offer precise and efficient gene editing solutions. Our core services include gene knockdown, knockout, and knock-in, enabling targeted genomic modifications with high accuracy.

CRISPR sgRNA Library Gene Knockdown Gene Knockin Gene Knockout Off-target Analysis

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Drug Target Models

GPCR Reporter Cells

Class A（Rhodopsin） Class B1（Secretin） Class C（Glutamate） Combination Orphan and other 7TM Parental Cell

Immunotherapy cells

Fc Effector Combination T Cell Activation Co-Stimulatory Co-Inhibitory Immune Checkpoint STING Cytokine&Growth Factor TAA TLR

Other Stable Cells

Signaling pathway cells Tracer Cell Nuclear Receptor Ion Channel Transporter Other

Assay Kits & Reagents

Assay Kits Reagents

Services

Stable Cell Line Development GPCR Cell-Based Assays Immuno-Oncology Cell Models Kinase Screening Platforms PROTAC Degradation Models ADC Target Cell Models Molecular Biology Services Drug Safety & Toxicology Gene Editing Services

Resources

Product Resource Learning

Company

About Us Careers Conferences&Events Contact us

Professional technology integration to support the entire R&D process

Home>Services>PROTAC Degradation Models

PROTAC Degradation Models

A key challenge in PROTAC development lies in accurately predicting and optimizing degradation efficacy, rather than mere binding affinity. Our PROTAC target model services are ...

PROTAC Degradation Assay Validation PROTAC Degradation Assay Optimization PROTAC Degradation Assay Development