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CCR3
CCR3 (C-C motif chemokine receptor 3) is a G protein-coupled receptor predominantly expressed on eosinophils, basophils and Th2 lymphocytes. Its endogenous ligands such as CCL11 activate Gi signaling, leading to reduced intracellular cAMP. CCR3 is a key therapeutic target for allergic rhinitis and other inflammatory airway diseases.Our CCR3 stable CHO-K1 cell lines have been validated in cAMP assays to support your drug discovery programs.