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CX3CR1 (GPR13) is a GPCR mainly expressed on monocytes, T cells and NK cells. CX3CL1 binding activates Gαi, inhibiting adenylate cyclase and reducing intracellular cAMP. It mediates cell survival, migration and proliferation, closely involved in immune regulation and inflammatory disorders, and serves as a key drug target for inflammatory diseases. Our CX3CR1 stable CHO-K1 cell lines have been validated in cAMP assays to support your drug discovery programs.