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MC5R is a receptor for α-MSH, widely expressed in muscle, fat, sebaceous glands and immune cells. Activation of MC5R mediates Gαs downstream signaling, regulating energy metabolism, sebum secretion and immune response. MC5R is an important target for metabolic and skin disease drug discovery. Our MC5R stable cell lines are validated for CRE-Luc reporter assays to support your drug discovery programs.