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CRTH2 (DP2, GPR44) is a GPCR mainly expressed on immune cells. Prostaglandin D2 binding activates Gαi/o, inhibiting adenylate cyclase and reducing intracellular cAMP. It mediates type 2 inflammatory responses, closely involved in asthma, allergic rhinitis and atopic dermatitis, and serves as a key drug target for inflammatory diseases. Our CRTH2 stable CHO-K1 cell lines have been validated in cAMP assays to support your drug discovery programs.