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5-HTR
The 5-hydroxytryptamine receptor (5-HTR) family is a key mediator of serotonin (5-HT) signaling. It comprises seven major classes (5-HT1–5-HT7) and 14 distinct subtypes, including both G protein-coupled receptors (GPCRs) and ligand-gated ion channels.Widely expressed across the central nervous system, peripheral tissues, and platelets, 5-HTRs regulate a broad range of physiological functions—from mood and cognition to cardiovascular activity, gastrointestinal motility, and pain perception.