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GPCR Reporter Cells

Immunotherapy cells

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GPCR Reporter Cells

Class A, B1 and C receptor models — 130+ targets in CRE-Luc, NFAT-Luc, β-arrestin and Gα15 formats, supplied with validation data and parental-cell controls.

Class A（Rhodopsin）

5-HTR ADORA1 ADORA2 ADORA3 ADRA1 ADRB1 ADRB2 AGTR1 APJ AVPR C3aR C5aR1 CB1 CB2 CCK2R CCR1 CCR10 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9 CHRM1 CHRM2 CHRM3 CHRM4 CHRM5 CRTH2 CX3CR1 CXCR1 CXCR2 CXCR3 CXCR4 CXCR5 CXCR6 CXCR7 DRD1 DRD2 DRD3 DRD4 DRD5 EDG1 EDNRA EDNRB FPR1 FPR2 FSHR GHSR GNRHR GPBAR1 GPR1 GPR10 GPR120 GPR146 GPR174 GPR183 GPR34 GPR35 GPR40 GPR43 GPR52 GPR54 GPR6 GPR84 GPR88 HCAR1 LHCGR LPA MAS1 MC1R MC2R MC3R MC4R MC5R MRGPR NK1R NK2R NK3R NMBR NPFFR2 NPY1R NPY2R NPY4R NPY5R NTSR1 NTSR2 OPRD1（DOR） OPRK1（KOR） OPRL1（NOP） OPRM1（MOR） OX1R OX2R OXTR PTGDR PTGER2 PTGER4 PTGIR RXFP1 RXFP2 SSTR1 SSTR2 SSTR3 SSTR4 SSTR5 TAAR1 TSHR

Class B1（Secretin）

CGRP CRF1R CRFR2 CTR GCGR GHRHR GIPR GLP1R GLP2R PAC1R PTH1R PTH2R SCTR VPAC1 VPAC2 XCR1

Class C（Glutamate）

CaSR GABA GPRC5D GRM2 GRM4

Combination

CALCRL/RAMP1 VPAC1 GLP1R CTR/RAMP3 GLP1R GCGR GLP1R GCGR GIPR GLP1R GIPR

Orphan and other 7TM

GPR55 GPR75

Parental Cell

Gα15(GNA15)

Class B2（Adhesion）

GPR133

Immunotherapy cells

Effector and target pairs for checkpoint and combination screening — PD-1, CTLA-4, TIGIT, LAG-3, 4-1BB, OX40 and SIRPα/CD47, with dual-reporter readouts and matched aAPCs.

Combination

CD155&CD112 CD47&PDL1 PD-1&IL2/IL15 PD1 BTLA PD1&41BB PD1&CTLA4 PD1&LAG3 PD1&OX40 PD1&TIGIT PDL1 PDL1 CD80&CD86 PDL1 HVEM PDL1&CD155 SIRPα&CD47 SIRPɑ&PD1 TIGIT&PVRIG

Fc Effector

ADCC/ADCP FcγR FcεRI

T Cell Activation

CD38 CD3E FOXP3 IL2 NFAT-Luc NFκB-Luc Other TCE TCR TCRαβ TCRαβ-CD3

Co-Stimulatory

4-1BB APRIL BAFF BCMA CD27-CD70 CD28-CD80/86 CD40 DR3-TL1A GITR-GITRL HVEM-LIGHT ICOS-ICOSL ICOSL LTBR NCR1 NCR3 NKG2D-MIC OX40 PGLYRP1 TACI TMIGD2-HHLA2 TREM1 TREM2

Co-Inhibitory

BTLA-HVEM CD160 CD161-CLEC2D CD200-CD200R CD96 CTLA4 HLA-G IGSF8 KIR2DL5A KIR2DL5B KIR3DL2 KIR3DL3-HHLA2 LAG3 LAIR1 LILRB1 LILRB2 LILRB4 Nectin4 NKG2A-HLA-E PD1-PDL1/2 PILR PVRIG-CD112 SIRPɑ-CD47 TIGIT-CD155 TIM-3 VISTA VSIG3

Immune Checkpoint

BDCA2 CD24 VSIG4

Cytokine&Growth Factor

Activin BMP BNP/NPR1 c-KIT CSF1R EGFR EPO ERBBs FGF21/KLB FGFR FGFR1 FGFR2 G-CSF GDF GHR GM-CSF GUCY2C IFN IGF1R IL1 IL10 IL11 IL12 IL17/IL25 IL18 IL19/IL20/IL22/IL24 IL2/IL15 IL21 IL22 IL23 IL27 IL3 IL31 IL33 IL36 IL4/IL13 IL5 IL6 IL7 IL9 Insulin Integrin MET NGF Notch1 NPR2 NTRK OSMR PDGF PRL RANK-RANKL TGF-β1 TIE2 TNFα TPO-TPOR TRKB TSLP VEGF WNT

TAA

5T4 ACP3 ADAM9 ALPP AMHR2 B7H3 B7H4 CD123 CD147 CD166 CD180 CD19 CD2 CD20 CD22 CD228 CD30 CD33 CD36 CD38 CD4 CD44 CD46 CD54 CD56 CD7 CD73 CD8 CD89 CD94 CD99 CDCP1 CDHs CEACAMs CLDN18.2 CLDN6 CLDNs CLEC12A CT83 DDR1 DLK1 DLLs DPP4 ENPP3 EрCAM FAP FCRL5 FRα GPC1 GPC3 GPC33 GPNMB HLA0201 KLK2 KLK2&STEAP1 LGR5&EGFR LRRC15 LY6E LY6G6D MERTK MSLN MUCs PRAME /HLA0201 PSMA PTGFRN PTK7 ROR1 ROR2 SEZ6 SLC34A2 SLC39A6 SLITRK6 SORT1 STEAP1 STEAP1B2 STEAP2 TF TFRC TM4SF1 TREM2 TROP2

Other

MUSK RSV

PRR

CLEC5A Dectin NOD1 NOD2 STING TLR2 TLR3 TLR4 TLR5 TLR7 TLR8 TLR9

Other Stable Cells

Pathway reporters — NFκB, STAT, CRE, SRE, NFAT, SBE — plus nuclear receptor, ion channel, transporter and tracer lines, for mechanism, selectivity and safety studies.

Signaling pathway cells

ARE-Luc cGMP-RE CRE-Luc GAL4-Luc NFAT-Luc NFκB-Luc SBE-Luc SRE.L-Luc STAT-Luc

Tracer Cell

HEK293 Jurkat E6.1 Raji THP-1

Nuclear Receptor

ESR1-GAL4 ESR1[D538G] ESR1[Y537S] FXR GR-GAL4 GRE-Luc IL4R&GR-GAL4 PPARδ-GAL4 RARα THRA THRB

Ion Channel

CAV1.2 L-TYPE Cav3.2 Cav3.3 ERG HCN4 Kv1.3 SCN5A(Nav1.5) TRPC TRPM8 TRPV4

Transporter

ASCT2 GAT1((SLC6A1) KCC2 MATE1 MATE2K OAT1 OAT3 OATP1B1 OATP1B3 OCT2 SGLT2 SLC6A2 SLC6A3 SLC6A4 URAT1 URAT1/URATV1

Other

AAK1/AP2M1 ALDH2 ALOX12 ALOX15 ALOX15B APP695 ASGR1 Caspas-1 LDLR Lnluc-LDLR LPA RAGE Tau [P301L] XIAP/CASP9

Assay Kits & Reagents

Assay-ready kits and matched reagents: detection solutions, media and controls qualified on the same cell models, so results hold from plate to plate and lab to lab.

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Stable Cell Line Development

We offer comprehensive solutions for stable cell line generation, including lentiviral integration, Flp-FRT site-specific integration, plasmid random integration, electroporation-based plasmid integration, and transposon-mediated integration.

Flp-FRT Targeted Integration Lentiviral Integration Plasmid Electroporation Random Plasmid Integration Transposon-Based Integration

GPCR Cell-Based Assays

Our GPCR assay services focus on the development, optimization, and validation of robust cellular models. These models are designed to accurately and reproducibly reflect compound-GPCR interactions, providing a reliable foundation for.... high-throughput screening and lead optimization.

GPCR Assay Development GPCR Assay Optimization GPCR Assay Validation

Immuno-Oncology Cell Models

We specialize in the development, optimization, and validation of cellular models for immuno-oncology targets. As your strategic partner, we are committed to enhancing your R&D success ...

Immuno-Oncology Assay Development Immuno-Oncology Assay Optimization Immuno-Oncology Assay Validation

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We provide end-to-end cell-based model development services for kinase-targeted drug screening. Our approach centers on the development, optimization, and validation of kinase assays at the ....

Kinase Assay Development Kinase Assay Optimization Kinase Assay Validation

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A key challenge in PROTAC development lies in accurately predicting and optimizing degradation efficacy, rather than mere binding affinity. Our PROTAC target model services are ...

PROTAC Degradation Assay Optimization PROTAC Degradation Assay Development PROTAC Degradation Assay Validation

ADC Target Cell Models

As ADC drug development advances beyond simple payload delivery, there is a growing need to evaluate differentiated mechanisms of action. Our ADC target model services provide a sophisticated platform for in-depth mechanistic insight.

ADC Assay Development ADC Assay Optimization ADC Assay Validation

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We deliver comprehensive and precise molecular biology solutions to support life science research and biopharmaceutical development. Key services include CRISPR-Cas9 sgRNA library synthesis, STR profiling, and quantitative real-time PCR.

Cell Line Authentication by NGS Digital PCR (dPCR) Quantitative PCR (qPCR) STR Authentication

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With extensive expertise in in vitro pharmacology, we continuously innovate to meet evolving industry needs. Our integrated evaluation system—spanning cell biology, biochemistry, and molecular biology—provides a complete suite of in vitro ...

Drug Safety and Toxicology Development

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Our core services include gene knockdown, knockout, and knock-in, enabling targeted genomic modifications with high accuracy.

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Drug Target Models

GPCR Reporter Cells

Class B2（Adhesion） Class A（Rhodopsin） Class B1（Secretin） Class C（Glutamate） Combination Orphan and other 7TM Parental Cell

Immunotherapy cells

Fc Effector Combination T Cell Activation Co-Stimulatory Co-Inhibitory Immune Checkpoint Cytokine&Growth Factor TAA Other PRR

Other Stable Cells

Signaling pathway cells Tracer Cell Nuclear Receptor Ion Channel Transporter Other

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Home>Drug Target Models>Immunotherapy cells>Combination>SIRPɑ&PD1

THP-1 Human SIRPɑ&PD1 Dual Effector Reporter Cell

Product Info

Description

Biological Information

Assay Data

Cell Culture

Classification	Combination
Family	Ig-like cell adhesion molecule family
Gene Name	SIRPA
Gene Aliases	SHPS1;SIRP;MYD-1;BIT;P84;SHPS-1;SIRPalpha;CD172a;SIRPalpha2; MFR;SIRP-ALPHA-1
Gene ID	140885
Accession Number	NM_001040023.2
UniProt Number	P78324
Protein Name	SHP substrate 1; SHPS-1
Protein Aliases	Bit;CD172 antigen-like family member A;Inhibitory receptor SHPS-1;Macrophage fusion receptor;MyD-1 antigen
Family-2	CD28 family
Gene Name-2	PDCD1
Gene Aliases-2	CD279;PD1;hSLE1;PD-1
Gene ID-2	5133
Accession Number-2	NM_005018.3
UniProt Number-2	Q15116
Protein Name-2	Protein PD-1;hPD-1
Protein Aliases-2	N/A
Target Species	Human
Host cell	THP-1