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ADORA2A is a Gs-coupled GPCR that stimulates adenylate cyclase upon adenosine binding, increasing intracellular cAMP levels. It is highly expressed in the brain striatum, immune cells, and coronary arteries, playing key roles in regulating motor function, immune responses, and vasodilation. As a critical target in Parkinson's disease, immuno-oncology, and ischemic cardiovascular diseases, ADORA2A offers broad therapeutic potential. We offer ADORA2A stable cell lines validated for cAMP accumulation and β-arrestin recruitment assays, ready for high-throughput screening and compound profiling.